So today I am on lead in Day -3. It is a no drug day, and I'm feeling fine, a bit worn out from the traveling. I returned from a round trip to SF yesterday, day -4, at 11:30 last night. I won't be back on drug until Day 1, Friday, when I get both drugs AND a lot of tests.
Day -4 I had to be there so they could draw from PK's and PD's of the drug. I napped most of the time, but it wasn't very restful with all the interruptions. They take blood several times and do a bunch of EKG's watching the Qt interval which is a common side effect of this drug. I didn't feel as fatigued by the drug, but I was napping anyway.
Day -5 and -6 were kind of rough. I felt very fatigued and ended up sleeping a lot. Also, the drugs seemed to have a laxative effect so I had to have a movement frequently and urgently. Other than the fatigue I didn't have any problems with bleeding, fever, chills, or anything that they normally ask about.
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